An outbreak of typhoid fever in Zurich, Switzerland, which involved seven customers and three employees of a city mall restaurant, was investigated by comparing three molecular typing methods: pulsed-field gel electrophoresis (PFGE), ribosomal RNA gene restriction patterns (ribotyping), and random amplified polymorphic DNA (RAPD). Both PFGE and ribotyping identified two molecular patterns among the outbreak-related isolates which differed in one band: these isolates were considered clonally related and differed clearly from other unrelated S. typhi strains. RAPD could not distinguish among outbreak isolates and control strains.