Karger Publishers, Cytogenetic and Genome Research, 3-4(45), p. 231-233, 1987
DOI: 10.1159/000132459
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The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12→qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (λHR5) could detect a <i>Hin</i>dIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.