Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 11(20), p. 3413-3415, 2010
DOI: 10.1016/j.bmcl.2010.04.002
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New dirhodium complex with activity towards colorectal cancer
Journal article published in 2010 by
Raquel F. M. Frade,
Nuno R. Candeias 
,
Catarina M. M. Duarte ,
Vânia Andre ,
M. Teresa Duarte ,
M. T. Duarte,
Pedro M. P. Gois ,
Carlos A. M. Afonso
,
Catarina M. M. Duarte ,
Vânia Andre ,
M. Teresa Duarte ,
M. T. Duarte,
Pedro M. P. Gois ,
Carlos A. M. Afonso
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Abstract
A novel dirhodium complex (Rh(2)(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.