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Wiley-VCH Verlag, ChemInform, 29(43), p. no-no, 2012

DOI: 10.1002/chin.201229203

Wiley, Archiv der Pharmazie, 3(345), p. 215-222, 2011

DOI: 10.1002/ardp.201100065

Wiley-VCH Verlag, Archiv der Pharmazie, 12(345), p. 1001-1001

DOI: 10.1002/ardp.201290012

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Synthesis and Biological Evaluation of Antitumor-Active Arglabin Derivatives

Journal article published in 2011 by René Csuk, Anke Heinold, Bianka Siewert, Stefan Schwarz ORCID, Alexander Barthel, Ralph Kluge, Dieter Ströhl
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Arglabin derivatives varied at the endo- or exo-cyclic double bond were synthesized and studied in a colorimetric sulforhodamine B assay for their cytotoxicity. Variations on the endocyclic double bond led to compounds of reduced cytotoxicity whereas derivatives from the reaction of the α-methylene-γ-butyrolactone moiety led to compounds of similar or only slightly reduced cytotoxicity but different, cell line-dependent selectivity. In addition, arglabin is an excellent starting material for the synthesis of the guaianolide arborescin.