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Elsevier, Bioorganic and Medicinal Chemistry Letters, 16(14), p. 4257-4261

DOI: 10.1016/j.bmcl.2004.06.002

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Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

Journal article published in 2004 by Diana Ivanova, Aurélie Rossin, Hinrich Gronemeyer ORCID, Alain Valla, Dominique Cartier, Régis Le Guillou, Régis Le Guillou, Roger Labia
This paper is available in a repository.
This paper is available in a repository.

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Abstract

New structure-activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.