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2010 IEEE International Workshop on Machine Learning for Signal Processing

DOI: 10.1109/mlsp.2010.5589258

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Ranking of gene regulators through differential equations and Gaussian processes

Proceedings article published in 2010 by Antti Honkela, Marta Milo, Matthew Holley, Magnus Rattray ORCID, Neil D. Lawrence ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Gene regulation is controlled by transcription factor proteins which themselves are encoded as genes. This gives a network of interacting genes which control the functioning of a cell. With the advent of genome wide expression measurements the targets of given transcription factor have been sought through techniques such as clustering. In this paper we consider the harder problem of finding a gene's regulator instead of its targets. We use a model-based differential equation approach combined with a Gaussian process prior distribution for unobserved continuous-time regulator expression profile. Candidate regulators can then be ranked according to model likelihood. This idea, that we refer to as ranked regulator prediction (RRP), is then applied to finding the regulators of Gata3, an important developmental transcription factor, in the development of ear hair cells.