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Springer Nature [academic journals on nature.com], Oncogene, 28(32), p. 3329-3338, 2012

DOI: 10.1038/onc.2012.344

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Epigenetic screen identifies genotype- specific promoter DNA methylation and oncogenic potential of CHRNB4

Journal article published in 2012 by David B. Scherf, Narek Sarkisyan, Hanna Jacobsson, Rainer Claus, Justo L. Bermejo, Barbara Peil, Lei Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Christoph Plass, Angela Risch ORCID
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This paper is available in a repository.

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Abstract

Genome-wide association studies have highlighted three major lung cancer susceptibility regions at 15q25.1, 5p15.33 and 6p21.33. To gain insight into the possible mechanistic relevance of the genes in these regions, we investigated the regulation of candidate susceptibility gene expression by epigenetic alterations in healthy and lung tumor tissues. For genes up- or downregulated in lung tumors the influence of genetic variants on DNA methylation was investigated and in vitro studies were performed.