Preparation, Purification and Regioselective Functionalization of Protoescigenin-The Main Aglycone of Escin Complex
Journal article published in 2013 by
Mariusz M. Gruza,
Kamil Jatczak,
Bogdan Zagrodzki,
Marta Łaszcz,
Marta Laszcz,
Katarzyna Koziak,
Maura Malińska,
Piotr Cmoch,
Tomasz Giller,
Oliwia Zegrocka-Stendel,
Krzysztof Woźniak 
,
Grzegorz Grynkiewicz
,
Grzegorz Grynkiewicz
This paper is made freely available by the publisher.
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Abstract
A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture-protoescigenin-was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.