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Elsevier, Metabolism, 9(59), p. 1316-1318, 2010

DOI: 10.1016/j.metabol.2009.12.006

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Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

Journal article published in 2010 by Louise E. Olofsson, Bob Olsson, Theodore Lystig, Peter Jacobson ORCID, Margareta Jernås, Kajsa Sjöholm, Anders Gummesson, Lars Sjöström, Per Eriksson, Anders Hamsten, Laura P. Hale, Dag S. Thelle ORCID, Björn Carlsson, Lena M. S. Carlsson
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Abstract

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.