Published in
American Association for the Advancement of Science, Science, 6232(348), p. 340-343, 2015
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- [www.ncbi.nlm.nih.gov] | PDF
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Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
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Christine L. Chaffer,
Nemanja Marjanovic,
Nalle Pentinmikko ,
Sharif Iqbal,
Roberto Zoncu,
Walter W. Chen,
Robert A. Weinberg,
David M. Sabatini
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Abstract
By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mammary stem-like cells and found that such cells apportion aged mitochondria asymmetrically between daughter cells. Daughter cells that received fewer old mitochondria maintained stem cell traits. Inhibition of mitochondrial fission disrupted both the age-dependent sub-cellular localization and segregation of mitochondria, and caused loss of stem cell properties in the progeny cells. Hence, mechanisms exist for mammalian stem-like cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties.