Typical examples from different morphological and geological settings in the Antarctic Ocean are reviewed in order to discuss the value of clay mineral assemblages for reconstructing the glacial history of Antarctica, the paleoceanographic history of the Antarctic Ocean and the sedimentary processes at the Antarctic continental margin. The significance of clay minerals for paleoenvironmental reconstructions strongly varies with both the position of the sites under investigation and the age of the sediments.In late Mesozoic to Paleogene sediments clay mineral assemblages are sensitive tools for reconstructing climatic conditions. For example, the shift from smectite-dominated assemblages to illite- and chlorite-dominated assemblages in the earliest Oligocene clearly documents the transition from chemical weathering conditions under a warm and humid climate to physical weathering under cooler conditions. Submarine elevations such as Maud Rise and Kerguelen Plateau give the best record for direct paleoclimatic and paleoceanographic studies. At the proximal sites of the continental slope and shelf, as well as in the deep sea, the paleoclimatic information normally is masked by a variety of processes resulting in sediment redistribution. At those sites, in contrast, the clay mineral assemblages bear a wealth of information on different sedimentary processes.After the establishment of a continental East Antarctic ice sheet, physical weathering prevailed. Variations in the clay mineral records predominantly reflect the influence of different sediment sources resulting from different glacial, hydrographic or gravitational transport processes. Because these sedimentation processes are generally linked to climatic variations, the clay mineral assemblages in most of the Neogene and Quaternary sediments provide indirect paleoclimatic information. The processes are best documented in the clay mineral composition in those areas where changes in source regions with distinct petrographic differences are expected and where distances from the source region are low.