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Nature Research, Nature Cell Biology, 8(13), p. 888-890, 2011

DOI: 10.1038/ncb2312

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FBXW5 controls centrosome number

Journal article published in 2011 by Julia Pagan ORCID, Michele Pagano
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.