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Wiley, FEBS Letters, 1(580), p. 285-290, 2005

DOI: 10.1016/j.febslet.2005.12.014

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Dehydroepiandrosterone increases β-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats

Journal article published in 2005 by Mayrin C. Medina, Lílian C. Souza, Luciana C. Caperuto ORCID, Gabriel F. Anhê, Angélica M. Amanso, Vicente P. A. Teixeira, Silvana Bordin ORCID, Angelo R. Carpinelli, Luiz R. G. Britto, Renato L. Barbieri, Maria I. Borella, Carla R. O. Carvalho ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The effect of dehydroepiandrosterone (DHEA) on pancreatic islet function of aged rats, an animal model with impaired glucose-induced insulin secretion, was investigated. The following parameters were examined: morphological analysis of endocrine pancreata by immunohistochemistry; protein levels of insulin receptor, IRS-1, IRS-2, PI 3-kinase, Akt-1, and Akt-2; and static insulin secretion in isolated pancreatic islets. Pancreatic islets from DHEA-treated rats showed an increased beta-cell mass accompanied by increased Akt-1 protein level but reduced IR, IRS-1, and IRS-2 protein levels and enhanced glucose-stimulated insulin secretion. The present results suggest that DHEA may be a promising drug to prevent diabetes during aging.