Published in
Elsevier, The Veterinary Journal, 3(189), p. 353-355, 2011
DOI: 10.1016/j.tvjl.2010.09.001
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In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids
,
Guido Invernizzi ,
Alessandro Agazzi,
Mariella Ferroni,
Laura Francesca Pisani ,
Giovanni Savoini ,
Fabrizio Ceciliani
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Abstract
The in vitro effects of the ω-3 polyunsaturated fatty acids (PUFAs) eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) on phagocytosis and the extracellular respiratory burst in caprine monocytes were assessed. Blood monocytes incubated with increasing concentrations of EPA or DHA (25-200 μM) demonstrated increased phagocytosis compared to unexposed monocytes. Generation of reactive oxygen species (ROS) was not markedly affected in the presence of EPA and DHA, except at 200 μM, at which concentrations monocyte viability was also reduced.