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Prostate-Specific Antigen Velocity for Early Detection of Prostate Cancer: Result from a Large, Representative, Population-based Cohort
Journal article published in 2009 by
Andrew J. Vickers 
,
Tineke Wolters,
Caroline J. Savage,
Angel M. Cronin,
M. Frank O'Brien,
M. Frank O’Brien,
Kim Pettersson,
Monique J. Roobol,
Gunnar Aus,
Peter T. Scardino,
Jonas Hugosson,
Fritz H. Schröder,
Hans Lilja
,
Tineke Wolters,
Caroline J. Savage,
Angel M. Cronin,
M. Frank O'Brien,
M. Frank O’Brien,
Kim Pettersson,
Monique J. Roobol,
Gunnar Aus,
Peter T. Scardino,
Jonas Hugosson,
Fritz H. Schröder,
Hans Lilja
Abstract
BACKGROUND: It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy. OBJECTIVE: To evaluate whether PSAV enhances prediction of biopsy outcome in a large, representative, population-based cohort. DESIGN, SETTING, AND PARTICIPANTS: There were 2742 screening-arm participants with PSA