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BioMed Central, Parasites and Vectors, 1(3), p. 43

DOI: 10.1186/1756-3305-3-43

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Increased transcription of Glutathione S-transferases in acaricide exposed scabies mites

Journal article published in 2010 by Kate E. Mounsey, Cielo J. Pasay, Larry G. Arlian, Marjorie S. Morgan, Deborah C. Holt ORCID, Bart J. Currie, Shelley Faye Walton, James S. McCarthy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Recent evidence suggests that Sarcoptes scabiei var. hominis mites collected from scabies endemic communities in northern Australia show increasing tolerance to 5% permethrin and oral ivermectin. Previous findings have implicated detoxification pathways in developing resistance to these acaricides. We investigated the contribution of Glutathione S-transferase (GST) enzymes to permethrin and ivermectin tolerance in scabies mites using biochemical and molecular approaches. Results Increased in vitro survival following permethrin exposure was observed in S. scabiei var. hominis compared to acaricide naïve mites (p