Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines
Journal article published in 1994 by
E. Alonso De Velasco,
E. A. DeVelasco,
H. A. T.-H. Dekker,
P. Antal,
K. P. Jalink,
J. A. G. van Strijp 
,
A. F. M. Verheul,
J. Verhoef,
H. Snippe
,
A. F. M. Verheul,
J. Verhoef,
H. Snippe
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Abstract
The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.