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Elsevier, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1(1402), p. 1-5, 1998

DOI: 10.1016/s0167-4889(98)00010-x

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Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium

Journal article published in 1998 by Chiya Kosaka, Meenal Khosla, Gerald Weeks, Catherine Pears ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid. Activating phosphorylation is markedly inhibited in strains overexpressing the constitutively activated RasG protein. This is in marked contrast to mammalian cells where the highly related mitogen-activated protein kinases (MAPKs) are stimulated by Ras activation.