Dissemin is shutting down on January 1st, 2025

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Oxford University Press (OUP), American Journal of Epidemiology, 9(168), p. 1091-1091

DOI: 10.1093/aje/kwn238

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Re: "Predictors of the Timing of Natural Menopause in the Multiethnic Cohort Study"

Journal article published in 2008 by Sunni L. Mumford ORCID, Reem Hasan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

The timing of natural menopause has implications for several health endpoints; in particular, it is a risk factor for breast cancer. The authors investigated factors influencing the timing of natural menopause among 95,704 women with a mean age of 59.7 years (10th-90th percentile range, 47.0-71.0) in five racial/ethnic groups in the Multiethnic Cohort Study, including non-Latina Whites, Japanese Americans, African Americans, Native Hawai'ians, and Lat- inas. The authors investigated whether race/ethnicity and several lifestyle and reproductive characteristics were associated with the timing of natural menopause. Race/ethnicity was a significant independent predictor of the timing of natural menopause. Other factors, including smoking, age at menarche, parity, and body mass index, did not significantly alter the race/ethnicity-specific hazard ratios. Relative to non-Latina Whites, natural menopause occurred earlier among Latinas (US-born Latinas: hazard ratio (HR) ¼ 1.10, 95% confidence interval (CI): 1.07, 1.14; non-US-born Latinas: HR ¼ 1.25, 95% CI: 1.21, 1.30) and later among Japanese Americans (HR ¼ 0.93, 95% CI: 0.90, 0.95). These results support the hypothesis that the timing of natural menopause is driven by a combination of genetic, reproductive, and lifestyle factors. cohort studies; continental population groups; epidemiologic factors; menopause