OBJECTIVE: To validate the neuroanatomical distribution of disease in clinical syndromes associated with frontotemporal degeneration (FTD) in Colombia. BACKGROUND: FTD is a clinically heterogeneous disorder that includes a behavioral variant (bvFTD) and two variants of primary progressive aphasia (PPA) characterized by non-fluent agrammatic speech (naPPA) and semantic deficits (svPPA). It is well established that each clinical syndrome has a distinct pattern of grey matter (GM) atrophy, but despite FTD affecting individuals worldwide, these distributions of GM disease have rarely been validated in Latin America. METHODS: We report the imaging characteristics of 19 bvFTD, 11 naPPA, and 6 svPPA patients diagnosed using international consensus criteria at the Institute on Aging, Pontificia Universidad Javeriana in Colombia. Images were compared to those of 31 healthy controls recruited at the center. All subjects completed a high resolution (1mm isotropic) T1-weighted MRI scan. All MRI volumes were processed using a state-of-the-art pipeline implemented in Advanced Normalization Tools (ANTs) and we derived registration-based voxelwise measures of cortical thickness. We report group differences between each FTD syndrome and healthy controls (p<0.05 FWE; k>50). RESULTS: Overall, we observed patterns of reduced GM cortical thickness that are consistent with previous reports. Relative to controls, bvFTD had reduced GM in anterior cingulate and right insular cortex, naPPA had reduced GM in left inferior frontal cortex extending to left superior, anterior and middle temporal cortex, and svPPA had reduced GM bilaterally in anterior temporal cortex. CONCLUSIONS: Together, these imaging findings converge with previous neuroimaging and pathological reports of FTD syndromes (Grossman, 2010, Seeley, et.al., 2008). The consistent distribution of GM disease in this Colombian cohort opens the way for cross-cultural imaging studies with specialized FTD sites in Latin America. Study supported by: AG046499, AG017586, AG032953, AG043503, Colciencias 371-2011 and 370-201, and Wyncote Foundation