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Wiley, Tissue Antigens, 0(0), p. 071030182930001-???, 2007

DOI: 10.1111/j.1399-0039.2007.00955.x

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Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.

Journal article published in 2007 by Svetlana Adamovic, S. S. Amundsen, Benedicte Alexandra Lie, Åsa Hellqvist, Audur H. Gudjonsdottir, Johan Ek, Staffan Nilsson, Jan Wahlström, Henry Ascher, Ludvig M. Sollid, Å. T. Naluai ORCID, Åsa Torinsson Naluai
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31–33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for linkage was obtained with a Zlr score of 3.96, Pnc = 4 × 10−5 at marker D5S436. The strongest association was with a haplotype consisting of the markers D5S2033 and D5S2490 (Pnc