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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(50), p. 368-370, 2006

DOI: 10.1128/aac.50.1.368-370.2006

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In Vitro Activity of Fosfomycin against Extended-Spectrum-β-Lactamase- Producing Escherichia coli and Klebsiella pneumoniae: Comparison of Susceptibility Testing Procedures

Journal article published in 2006 by M. de Cueto, L. López, J. R. Hernández, C. Morillo, A. Pascual ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The agar dilution, broth microdilution, and disk diffusion methods were compared to determine the in vitro susceptibility of 428 extended-spectrum- β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae to fosfomycin. Fosfomycin showed very high activity against all ESBL-producing strains. Excellent agreement between the three susceptibility methods was found for E. coli, whereas marked discrepancies were observed for K. pneumoniae. Copyright © 2006, American Society for Microbiology. All Rights Reserved.