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American Chemical Society, Organic Letters, 4(7), p. 697-700, 2005

DOI: 10.1021/ol047482u

Wiley-VCH Verlag, ChemInform, 28(36), 2005

DOI: 10.1002/chin.200528151

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Hiyama Cross-Coupling of Chloro-, Fluoro-, and Methoxypyridyltrimethylsilanes: Room-Temperature Novel Access to Functional Bi(het)aryl

Journal article published in 2005 by Philippe Gros, Philippe Pierrat ORCID, Yves Fort
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The incorporation of chloro, fluoro, or methoxy substituents on the pyridine ring of pyridyltrimethylsilanes allowed us to perform efficient Hiyama cross-coupling with various (het)aryl halides. The reactions proceeded smoothly at room temperature leading to the corresponding functional bis(het)aryl in fair to excellent yields. The presence of pyridine nitrogen alpha to the trimethylsilyl group was requisite to achieve the cross-coupling. [Reaction: see text]