Published in
Elsevier, Structure, 12(21), p. 2095-2097, 2013
DOI: 10.1016/j.str.2013.11.003
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Hitting a Moving Target: Targeting Transient Protein States
Journal article published in 2013 by
Matthias R. Bauer 
,
Frank M. Boeckler
,
Frank M. Boeckler
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Abstract
In this issue of Structure, Bista and colleagues report that inhibitors of the MDM2/p53 interaction can be designed to interact with a transiently folded α-helical segment of the MDM2 lid region. This suggests that targeting transient protein states in PPI inhibitor design could be a promising strategy to improve affinity and/or selectivity profiles.