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Wiley, Angewandte Chemie International Edition, 11(49), p. 1971-1975, 2010

DOI: 10.1002/anie.200906482

Wiley, Angewandte Chemie, 11(122), p. 2015-2019, 2010

DOI: 10.1002/ange.200906482

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Strongly Binding Cell-Adhesive Polypeptides of Programmable Valencies

Journal article published in 2010 by Benjamin W. Lee, Rajib Schubert ORCID, Yuk Kee Cheung, Federico Zannier, Qian Wei, Daniele Sacchi, Samuel K. Sia
This paper is available in a repository.
This paper is available in a repository.

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Abstract

(Chemical Equation Presented) Longer and stronger: Engineered multivalent polypeptides were used to increase and tune the adhesion strength of cells to surfaces. Monodisperse polypeptides containing programmable valencies of a cell-adhesion sequence were synthesized (with up to 80 repeats of the RGD sequence; see schematic illustration). The multivalent cell-adhesion polypeptides provided strong resistance to cellular delamination under shear.