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American Chemical Society, Organic Letters, 6(5), p. 921-923, 2003

DOI: 10.1021/ol0341039

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Preparation of the 4-Hydroxytryptamine Scaffold via Palladium-Catalyzed Cyclization: A Practical and Versatile Synthesis of Psilocin

Journal article published in 2003 by Nicholas Gathergood, Peter John Scammells ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

[reaction: see text] The 4-hydroxytryptamine scaffold of psilocin was successfully prepared via palladium-catalyzed cyclization of protected N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline and an appropriately substituted silyl acetylene. Removal of the protecting groups afforded psilocin in good yield.