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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 6-7(26), p. 761-765, 2007

DOI: 10.1080/15257770701499069

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Thermodynamic Analysis Of Quadruplex Dna-Drug Interaction

Journal article published in 2007 by Bruno Pagano, Carlo A. Mattia, Ada Virno, Antonio Randazzo, Luciano Mayol ORCID, Concetta Giancola
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This paper is available in a repository.

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Abstract

This work studies the binding properties of distamycin and its carbamoyl analog, containing four pyrrole units, with the [d(TGGGGT)](4) quadruplex by means of isothermal titration calorimetry (ITC). Analysis of the ITC data reveals that drug/quadruplex binding stoichiometry is 1:1 for both interactions and that distamycin analog gives approximately a 10-fold increase in the quadruplex affinity.