Published in

18th IEEE Symposium on Computer-Based Medical Systems (CBMS'05)

DOI: 10.1109/cbms.2005.10

Links

Tools

Export citation

Search in Google Scholar

A grid-based stochastic simulation of unitary and membrane Ca2+ currents in spherical cells

Proceedings article published in 2005 by V. Gonzalez Velez, H. González-Vélez ORCID, H. Gonzalez Velez
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO

Abstract

We present a stochastic simulation of L-type Ca2+ current assuming thousands of calcium channels on the membrane of a spherical cell. We propose a three-state Markov model to simulate the individual contribution of each channel. Rather than using a statistical approximation, we actually consider each individual channel transitions between states and evaluate the unitary channel current. We compare this aggregated unitary contributions with simulated whole cell currents, both in response to a depolarising voltage pulse. On the computational side, we have employed a parameter-sweep, component based approach. Being embarrassingly parallel by design, we have parallelised it in a naive manner. We argue its possible extension using algorithmic skeletons. The results presented account for hours of processing time on a dedicated grid.