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Elsevier, Brain Research, 1-2(517), p. 344-346, 1990

DOI: 10.1016/0006-8993(90)91048-l

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The effect of systemic cocaine on spontaneous and nociceptively evoked activity of neurons in the medial and lateral thalamus

Journal article published in 1990 by Jr. Carl R. Belczynski, {C R} Belczynski, Antti Pertovaara ORCID, Thomas J. Morrow, {T J} Morrow, Kenneth L. Casey, {K L} Casey
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Abstract

In rats, analgesic doses of cocaine (25 mg/kg, i.p.) suppressed the responses of 20 of 22 medial and lateral thalamic neurons to reticular formation and somatic noxious stimuli. The responses of 7 of 8 lateral thalamic neurons to innocuous somatic stimuli were unaffected or enhanced. The suppression of thalamic responses to noxious stimuli may be part of the mechanism underlying cocaine analgesia.