Published in

Elsevier, Genomics, 2(81), p. 149-156, 2003

DOI: 10.1016/s0888-7543(02)00027-7

Links

Tools

Export citation

Search in Google Scholar

Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages☆☆Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under Accession Nos. AY134884–AY134891 and AF532734–AF532738.

Journal article published in 2003 by Anton Buzdin, Svetlana Ustyugova, Konstantin Khodosevich ORCID, Ilgar Mamedov, Yuri Lebedev, Gerhard Hunsmann, Eugene Sverdlov
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Using 40 known human-specific LTR sequences, we have derived a consensus sequence for an evolutionary young HERV-K (HML-2) LTR family, which was named the HS family. In the human genome the HS family is represented by approximately 150-160 LTR sequences, 90% of them being human-specific (hs). The family can be subdivided into two subfamilies differing in five linked nucleotide substitutions: HS-a and HS-b of 5.8 and 10.3 Myr evolutionary ages, respectively. The HS-b subfamily members were transpositionally active both before the divergence of the human and chimpanzee ancestor lineages and after it in both lineages. The HS-a subfamily comprises only hs LTRs. These and other data strongly suggest that at least three "master genes" of HERV-K (HML-2) LTRs were active in the human ancestor lineage after the human-chimpanzee divergence. We also found hs HERV-K (HML-2) LTRs integrations in introns of 12 human genes and identified 13 new hs HERV-K (HML-2) LTRs.