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Elsevier, Fertility and Sterility, 8(95), p. 2651-2654, 2011

DOI: 10.1016/j.fertnstert.2011.01.129

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CD4(+)CD28(null) T lymphocytes are expanded in young women with polycystic ovary syndrome

Journal article published in 2011 by Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino ORCID, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Bacà, Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea
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Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4(+)CD28(null) T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS. (Fertil Steril (R) 2011;95:2651-4. (C) 2011 by American Society for Reproductive Medicine.)