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Elsevier, Annals of Oncology, 1(26), p. 185-192, 2015

DOI: 10.1093/annonc/mdu490

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Differences among young adults, adults, and elderly chronic myeloid leukemia patients

Journal article published in 2014 by Fausto Castagnetti, G. Gugliotta, M. Baccarani, M. Breccia, G. Specchia, L. Levato, E. Abruzzese, G. Rossi, A. Iurlo, B. Martino, P. Pregno, F. Stagno, A. Cuneo, M. Bonifacio, M. Gobbi and other authors.
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This paper is available in a repository.

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Abstract

BACKGROUND: The incidence of chronic myeloid leukemia (CML) increases with age, but it is unclear how the characteristics of the disease vary with age. In children, where CML is very rare, it presents with more aggressive features, including huge splenomegaly, higher cell count and higher blast cell percentage. PATIENTS AND METHODS: To investigate if after childhood the disease maintains or loses these characteristics of aggressiveness, we analyzed 2784 adult patients, at least 18 years old, registered by GIMEMA CML WP over a 40-year period. RESULTS: Young adults (YAs: 18-29 years old) significantly differed from adults (30-59 years old) and elderly patients (at least 60 years old) particularly for the frequency of splenomegaly (71%, 63% and 55%, P