A study was conducted to demonstrate one-pot solution synthesis of cubic cobalt (Co) nanoskeletons by introducing etchant into the in situ reduction process. The nanoskeletons exhibited superior magnetic properties as compared with the solid cube-like aggregates and nanocages, due to their increased shape anisotropy. Cubic Co nanoskeletons were obtained when a mixed dispersion of cobalt acetate tetrahydrate (Co(Ac)2 · 4H2O) and sodium fluoride (NaF) was heated at 180 °C for 48-60 hours in absolute ethanol. The X-ray diffraction (XRD) pattern of the product indicated the crystalline nature of the Co. Field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and high-resolution TEM (HRTEM) images also provided more information about the nanostructure and morphology of the Co nanoskeletons.