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Michigan Publishing, Arkivoc, 9(2011), p. 125-141, 2011

DOI: 10.3998/ark.5550190.0012.909

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High-throughput preparation of alkyl 4-aryl substituted-2-methyl-6- thioxo-1,4,5,6-tetrahydropyridine-3-carboxylates under microwave irradiation

Journal article published in 2011 by Hortensia Rodriguez, Julieta Coro, Anabel Lam ORCID, Esperanza Salfrán, Javier Rodríguez-Salarichs ORCID, Margarita Suárez, Fernando Albericio, Nazario Martín ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

An efficient high-throughput synthesis of 4-aryl substituted 1,4,5,6-tetrahydro-2-methyl-6-thioxopyridine-3-carboxylates 5a-p was developed by using Lawesson's reagent, a very effective thionating reagent for carbonyl compounds, under conventional conditions and microwave irradiation. In order to gain a better understanding of the structure of the heterocycles obtained, theoretical calculations at the ab initio level were carried out.