Published in
Elsevier, EBioMedicine, 11(2), p. 1677-1685, 2015
DOI: 10.1016/j.ebiom.2015.09.031
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Associated links among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium
,
Rayjean J. Hung,
Yongyue Wei,
Hung Rj,
Geoffrey Liu,
Zuo-Feng Zhang,
Li Su,
Yun-Chul Hong,
Ruyang Zhang,
Jin Hee Kim ,
Xuchen Zong,
Ann G. Schwartz,
Michael W. Marcus
and other authors.
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Abstract
A strong association between smoking and SCLC is noted whereas the dose–response relationships are less clear. We demonstrate that cumulative smoking of the first 50 pack-years is associated with a sharper increase in SCLC risk. Moreover, although the relationship between smoking and COPD or COPD and SCLC is well-established, no study has investigated the causal pathway among smoking, COPD, and SCLC. Here we reveal the risks of smoking behaviors on SCLC which are partially mediated (up to 7.6%) through COPD. The findings warrant further experimental study to elucidate the mechanisms in this causal pathway.