Published in

Elsevier, EBioMedicine, 11(2), p. 1677-1685, 2015

DOI: 10.1016/j.ebiom.2015.09.031

Links

Tools

Export citation

Search in Google Scholar

Associated links among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

Journal article published in 2015 by Erik H. F. M. van der Heijden, dummy-Author_name, Ruyi Huang ORCID, Rayjean J. Hung, Yongyue Wei, Hung Rj, Geoffrey Liu, Zuo-Feng Zhang, Li Su, Yun-Chul Hong, Ruyang Zhang, Jin Hee Kim ORCID, Xuchen Zong, Ann G. Schwartz, Michael W. Marcus and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

A strong association between smoking and SCLC is noted whereas the dose–response relationships are less clear. We demonstrate that cumulative smoking of the first 50 pack-years is associated with a sharper increase in SCLC risk. Moreover, although the relationship between smoking and COPD or COPD and SCLC is well-established, no study has investigated the causal pathway among smoking, COPD, and SCLC. Here we reveal the risks of smoking behaviors on SCLC which are partially mediated (up to 7.6%) through COPD. The findings warrant further experimental study to elucidate the mechanisms in this causal pathway.