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Lippincott, Williams & Wilkins, The Pediatric Infectious Disease Journal, 9(31), p. 964-969, 2012

DOI: 10.1097/inf.0b013e318263280e

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Humoral Antibody Response after Receipt of Inactivated Seasonal Influenza Vaccinations one Year Apart in Children

Journal article published in 2012 by Sophia Ng, Vicky J. Fang, Dennis K. M. Ip, Susan S. Chiu, Gabriel M. Leung, J. S. Malik Peiris ORCID, J. S. Malik Peiris, Benjamin J. Cowling ORCID
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This paper is available in a repository.

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Abstract

In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to subjects 6–15 years of age in two consecutive years. Receipt of TIV in year 2 induced seroprotection in most subjects. Among 39 children who received TIV in the second year, receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt of TIV in the first year.