Published in
Elsevier, Bioorganic and Medicinal Chemistry, 8(10), p. 2663-2669
DOI: 10.1016/s0968-0896(02)00091-3
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Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers
Journal article published in 2002 by
Elisa Perissutti,
Giuseppe Caliendo,
Vincenzo Santagada,
Ferdinando Fiorino,
Beatrice Severino,
Roberta d'Emmanuele di Villa Bianca 
,
Laura Lippolis,
Aldo Pinto,
Raffaella Sorrentino
,
Laura Lippolis,
Aldo Pinto,
Raffaella Sorrentino
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Abstract
As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i).