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Taylor and Francis Group, Journal of Biopharmaceutical Statistics, 4(24), p. 908-923

DOI: 10.1080/10543406.2014.901346

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Sample Size Determination in Shared Frailty Models for Multivariate Time-to-Event Data

Journal article published in 2014 by Liddy M. Chen, Joseph G. Ibrahim, Haitao Chu ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The frailty model is increasingly popular for analyzing multivariate time-to-event data. The most common model is the shared frailty model. Although study design consideration is as important as analysis strategies, sample size determination methodology in studies with multivariate time-to-event data is greatly lacking in the literature. In this paper, we develop a sample size determination method for the shared frailty model to investigate the treatment effect on multivariate event times. We analyzed the data using both a parametric model and a piecewise model with unknown baseline hazard, and compare the empirical power with the calculated power. Last, we discuss the formula for testing the treatment effect on recurrent events.