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Springer Nature [academic journals on nature.com], Molecular Psychiatry, 4(21), p. 547-553, 2015

DOI: 10.1038/mp.2015.63

Springer Nature [academic journals on nature.com], Molecular Psychiatry, 4(21), p. 585-585, 2015

DOI: 10.1038/mp.2015.118

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Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Journal article published in 2015 by T. G. M. van Erp, N. E. M. van Haren, van Erp Tg, D. P. Hibar, Hibar Dp, Lars T. Westlye ORCID, Rasmussen Jm, J. M. Rasmussen, D. C. Glahn, Glahn Dc, G. D. Pearlson, Pearlson Gd, O. A. Andreassen, I. Agartz, Andreassen Oa and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=-0.46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12), as well as larger pallidum (d=0.21) and lateral ventricle volumes (d=0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.Molecular Psychiatry advance online publication, 2 June 2015; doi:10.1038/mp.2015.63.