Published in
Nature Research, Nature Genetics, 6(37), p. 590-592, 2005
DOI: 10.1038/ng1571
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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Journal article published in 2005 by
Philip Stephens,
Sarah Edkins 
,
Helen Davies,
Chris Greenman,
Charles Cox,
Chris Hunter ,
Graham Bignell,
Jon Teague,
Raffaella Smith,
Claire Stevens,
Sarah O'Meara,
Adrian Parker,
Patrick Tarpey,
Tim Avis,
Andy Barthorpe
and other authors.
,
Helen Davies,
Chris Greenman,
Charles Cox,
Chris Hunter ,
Graham Bignell,
Jon Teague,
Raffaella Smith,
Claire Stevens,
Sarah O'Meara,
Adrian Parker,
Patrick Tarpey,
Tim Avis,
Andy Barthorpe
and other authors.
This paper is made freely available by the publisher.
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Abstract
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.