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Wiley, Angewandte Chemie, 26(126), p. 6805-6809, 2014

DOI: 10.1002/ange.201403588

Wiley, Angewandte Chemie International Edition, 26(53), p. 6687-6691

DOI: 10.1002/anie.201403588

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Synthetic Disialyl Hexasaccharides Protect Neonatal Rats from Necrotizing Enterocolitis

Journal article published in 2014 by Hai Yu, Kam Lau, Vireak Thon, Mengyang Xue, Yanhong Li, Go Sugiarto, Jingyao Qu, Shengmao Mu, Chloe A. Autran, Evelyn Jantscher-Krenn ORCID, Li Ding, Lars Bode, Xi Chen
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.