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Public Library of Science, PLoS ONE, 5(9), p. e96659, 2014

DOI: 10.1371/journal.pone.0096659

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Lactobacillus crispatus Dominant Vaginal Microbiome Is Associated with Inhibitory Activity of Female Genital Tract Secretions against Escherichia coli

Journal article published in 2014 by Jeny P. Ghartey, Benjamin C. Smith, Zigui Chen ORCID, Niall Buckley, Yungtai Lo, Adam Jonathan Ratner, Betsy C. Herold, Robert D. Burk
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Objective: Female genital tract secretions inhibit E. coli ex vivo and the activity may prevent colonization and provide a biomarker of a healthy microbiome. We hypothesized that high E. coli inhibitory activity would be associated with a Lactobacillus crispatus and/or jensenii dominant microbiome and differ from that of women with low inhibitory activity. Study Design: Vaginal swab cell pellets from 20 samples previously obtained in a cross-sectional study of near-term pregnant and non-pregnant healthy women were selected based on having high (>90% inhibition) or low (