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Wiley, Angewandte Chemie International Edition, 20(43), p. 2671-2674, 2004

DOI: 10.1002/anie.200453900

Wiley, Angewandte Chemie, 20(116), p. 2725-2728, 2004

DOI: 10.1002/ange.200453900

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High‐Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

Journal article published in 2004 by Mike Schutkowski Dr, Mike Schutkowski, Ulf Reimer, Ulf Reimer Dr, Sören Panse, Liying Dong, Liying Dong Dr, Jose M. Lizcano Dr, Jens Schneider-Mergener Prof. Dr, Jens Schneider-Mergener, Dario R. Alessi Prof. Dr ORCID
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Abstract

Thousands of kinase assays at one stroke are possible by using high-content peptide microarrays. Such experiments deliver information regarding peptidic kinase substrates and accelerate the development of high-throughput screening assays. Moreover, knowledge-based selection of human sequences allows the reliable detection of downstream targets of protein kinases, as demonstrated for 3-phosphoinositide-dependent protein kinase.