Published in

Wiley, Angewandte Chemie International Edition, 32(46), p. 6167-6171, 2007

DOI: 10.1002/anie.200702178

Wiley, Angewandte Chemie, 32(119), p. 6279-6283, 2007

DOI: 10.1002/ange.200702178

Links

Tools

Export citation

Search in Google Scholar

Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Marine Macrolide

Journal article published in 2007 by Ian Paterson, Kate Ashton, Robert Britton, Giuseppe Cecere, Gaëlle Chouraqui, Gordon J. Florence ORCID, Jonathan Stafford
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

(Chemical Equation Presented) Actin class: A stereoselective synthesis of the microfilament-destabilizing cytotoxic macrolide (-)-reidispongiolide A, isolated from the marine sponge Reidispongia coerulea, uses a convergent aldol-based strategy to construct the 26-membered macrolactone, followed by a coupling with an N-vinylformamide subunit. This constitutes the first synthesis of any member of the reidispongiolide/sphinxolide family.