Wiley, Angewandte Chemie International Edition, 32(46), p. 6167-6171, 2007
Wiley, Angewandte Chemie, 32(119), p. 6279-6283, 2007
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(Chemical Equation Presented) Actin class: A stereoselective synthesis of the microfilament-destabilizing cytotoxic macrolide (-)-reidispongiolide A, isolated from the marine sponge Reidispongia coerulea, uses a convergent aldol-based strategy to construct the 26-membered macrolactone, followed by a coupling with an N-vinylformamide subunit. This constitutes the first synthesis of any member of the reidispongiolide/sphinxolide family.