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Optica, Biomedical Optics Express, 10(4), p. 2257, 2013

DOI: 10.1364/boe.4.002257

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Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Journal article published in 2013 by M. Mazurenka, L. Di Sieno, G. Boso, D. Contini, A. Pifferi ORCID, A. Dalla Mora, A. Dalla Mora, A. Tosi, H. Wabnitz, R. Macdonald
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy- and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.