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BioMed Central, Gut Pathogens, 1(4), 2012

DOI: 10.1186/1757-4749-4-20

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Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia

Journal article published in 2012 by Ramani Baddam, Narender Kumar, Sabiha Shaik, Tiruvayipati Suma, Soo Tein Ngoi ORCID, Kwai-Lin Thong ORCID, Niyaz Ahmed
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Salmonella Typhi is a human restricted pathogen with a significant number of individuals as asymptomatic carriers of the bacterium. Salmonella infection can be effectively controlled if a reliable method for identification of these carriers is developed. In this context, the availability of whole genomes of carrier strains through high- throughput sequencing and further downstream analysis by comparative genomics approaches is very promising. Herein we describe the genome sequence of a Salmonella Typhi isolate representing an asymptomatic carrier individual during a prolonged outbreak of typhoid fever in Kelantan, Malaysia. Putative genomic coordinates relevant in pathogenesis and persistence of this carrier strain are identified and discussed.