Solar radiation is the best option and cost effective energy resources of this globe. Only a few stations are there in developing and under developed countries including Nepal to monitor solar radiation and sunshine hoursto generate a rational and accurate solar energy database. In this study, daily global solar radiation, and ubiquitous meteorological data (temperature and relative humidity) rather than rarely available sunshine hours have been used for Biratnagar, Kathmandu, Pokhara and Jumla to derive regression constants and hence to develop an empirical model. The model estimated global solar radiation is found to be in close agreement with measured values of respective sites. The estimated values were compared with Angstrom-Prescott model and examined using the statistical tools. Thus, the linear regression technique can be used to develop model at any location in the world. The resultant model may then be used to estimate the missing data of solar radiation for the respective sites and also can be used to estimate global solar radiation for the locations of similar geographic and meteorological characteristic.