This contribution describes objectives and technology of the European LabOnFoil project, which combines 15 partners from 8 different countries for development of ultra-low-cost lab-on-chip systems and validation of the technical results in four different applications. The novel approach of the project is the combination of optoelectronic circuits which monolithically integrated light emitter and detector by OLED-on-CMOS deposition with microfluidic parts manufactured in SU8 on wafer-scale level. The future mass production of these novel diagnostic components will be guaranteed by the development of manufacturing equipment. This will provide, at last, a standardized solution to manufacture truly ultra-low-cost Lab-on-a-chip microsystems.