In this study, we compare three desalination based alternatives for water supply in off-grid areas, and assess their environmental footprint. The three options are: (a) a solar still, (b) a photo-voltaic (PV) powered reverse osmosis (RO) unit, and (c) water delivery by truck from a central RO plant. By use of life-cycle analysis (LCA), a comprehensive environmental modeling of the three systems is carried out. The basic systems, components and processes are modeled, and then varied, in order to offer a deeper insight into the robustness of the model.Our findings indicate that energy generation and materials usage are critical parameters when the considered alternative options are compared. Of the three options, PV-RO is found to have the least environmental impact. The usefulness of this study is that it provides policy-makers insights into renewable energy desalination for clean water production and, thus, it promotes the deployment of low-carbon desalination technologies.