Study Design Systematic review of the literature. Objectives To review and assess the peer-reviewed literature on the effectiveness of physical therapy interventions in treating lumbopelvic pain during pregnancy. Background Current guidelines on interventions for lumbopelvic pain during pregnancy differ in regard to recommendations for assessment and intervention. Recent publications may allow revising current recommendations for the treatment of this complex problem. Methods An electronic search strategy was conducted using Pubmed, PEDro, Scopus and Cinahl covering the literature from January 1992 to November 2013.Two authors independently assessed all abstracts for eligibility. Articles were independently rated for quality by 2 authors using the criteria for methodological quality of the Cochrane Back Review Group. If possible, effect sizes were calculated for the different interventions. Results A total of 22 articles (all randomized controlled trials) reporting on 22 independent studies were included. Overall, the methodological quality of the studies was moderate. Data for 4 types of interventions were considered: a combination of interventions (7 studies, n=1543), exercise therapy (9 studies, n=2059), manual therapy (5 studies, n=360), and material support (1 study, n=115). Conclusion All included studies on exercise therapy, and most of the studies on interventions combined with patient education, reported a positive effect on pain, disability, and/or sick leave. Evidence-based recommendations can be made for the use of exercise therapy for the treatment of lumbopelvic pain during pregnancy. Level of Evidence Therapy, level 1a -. J Orthop Sports Phys Ther, Epub 10 May 2014. doi:10.2519/jospt.2014.5098.